Microbial production of hyaluronic acid: the case of an emergent technology in the bioeconomy

In 1988 a novel fermentation route to high molecular weight hyaluronan mediated by Streptococcus zooepidemicus was first reported. few years, following rapidly expanding demand for as key ingredient of facial dermal fillers, streptococcal production commercialized, in Western Europe and North America, subsequently China. Outlining the case microbial hyaluronan, an emergent technology bioeconomy, purpose this study is further advance field sustainable, high-added-value, biobased production. The recounts how bioproduction actually developed, its advantages, current limitations. research educational outcomes offer useful lessons bioeconomy scholars practitioners. © 2021 Authors. Biofuels, Bioproducts Biorefining published Society Industrial Chemistry John Wiley & Sons Ltd.